NexoBrid (Anacaulase) Benefits | NexoBrid Side effects, Doses

This NexoBrid has been approved in 42 countries. NexoBrid is a topical treatment utilized to eliminate eschar resulting from severe burns. It offers a novel method for burn care that swiftly and precisely removes dead tissue without causing damage to surrounding healthy tissue.

Overview

Medicine Name	NexoBrid or Anacaulase
Manufacturer	MediWound Ltd.
Type	Topical biological product
Approved from	42 countries
Use	Remove nonviable burn tissue (Eschar)

Indication: NexoBrid is used to remove dead tissue from deep partial and full-thickness burns.

Mechanism: It works by using a concentrated formula of enzymes, particularly bromelain, which effectively breaks down the dead tissue to promote the growth of new and healthy skin.

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NexoBrid Ingredients

This is a specialized product designed to remove dead tissue (eschar) resulting from severe burns. It presents a fresh method in burn treatment as it swiftly and carefully removes damaged tissue without affecting healthy skin. Important characteristics of NexoBrid include:

NexoBrid Uses

NexoBrid (Anacaulase) Benefits NexoBrid Side effects, Doses, skondor.com

NexoBrid is primarily used for treating severe burns, and it has specific applications in this area.

Eschar Removal: NexoBrid is utilized to eliminate eschar resulting from severe burns, which can impede healing and raise infection risks. Removing eschar with NexoBrid helps foster the growth of healthy tissue, enhancing the healing process.
Selective Debridement: NexoBrid provides a selective debridement process that targets only the necrotic tissue, leaving the surrounding healthy skin unaffected, unlike invasive traditional surgical debridement that can harm healthy tissue.
Minimized Surgical Intervention: NexoBrid can reduce the necessity for complex surgeries and grafting procedures, potentially improving patient results and speeding up the recovery process for healthcare providers.
Clinical Approval: NexoBrid has been tested in clinical trials and received approval from the FDA in the United States, as well as in Europe and other global markets.

NexoBrid Side Effects

NexoBrid, a topical treatment used to remove dead tissue from severe burns, can potentially cause a range of side effects, from severe to mild.

Serious Side Effects:

If you experience any of the following symptoms while using NexoBrid, it is important to seek medical attention promptly:

Pale skin, difficulty breathing, abnormal bleeding or bruising, or unusual fatigue or weakness.
Bladder discomfort, bloody or cloudy urine, vision changes, or confusion.
Cough, hoarseness, or painful urination.
Dizziness, fainting, or light headedness upon sudden standing.
Eye pain, rapid or irregular heartbeat, fever, chills, or a sore throat.
Abdominal pain or excessive sweating.
Tightness in the chest or trouble swallowing.
Development of hives, itching, or a skin rash.
Swelling around the face, eyes, tongue or lips.

Since there may be other side effects not listed here, it is advisable to consult your healthcare provider if you notice any unusual symptoms.

Less Severe Side Effects:

These side effects are typically not urgent and might improve as your body gets used to the medication:

Difficulty sleeping or vomiting.
Common occurrence of scar formation.
Common adverse reactions include itching and fever.
Insomnia can be a side effect.
Urinary tract infections may occur.
Complications with wounds, such as skin graft problems.
Anemia, low blood pressure, and bruising under the skin.
Abnormal liver function.
Rare hypersensitivity reactions, like severe allergic reactions and hives (reported after the medication was on the market).
Tachycardia is a condition that occurs in 1% to 10% of cases.
Itchiness (common), pressure ulcers, skin irritation, and marks.
Conditions like anemia, increased white blood cell count, and bruising under the skin.
Adverse reactions such as anaphylaxis and hives that involve hypersensitivity.
Difficulties with skin grafts can lead to complications with wounds.
Fever and difficulty sleeping are common symptoms.

NexoBrid Benefits

Let’s examine the advantages of NexoBrid, the topical solution used to remove eschar in serious burn wounds.

Rapid Debridement: NexoBrid efficiently eliminates eschar in as little as four hours. This quick removal of dead tissue aids in avoiding issues and supports quicker recovery.
Selective Action: NexoBrid provides a selective debridement process that targets only the dead tissue, without harming the healthy surrounding skin, unlike traditional surgical debridement methods.
Minimized Surgical Intervention: Healthcare providers can lessen the requirement for invasive surgeries by utilizing NexoBrid, which ultimately helps to decrease patient discomfort and speed up the healing process.
Improved Patient Outcomes: NexoBrid helps improve long-term outcomes by protecting healthy tissue, which in turn promotes the ideal conditions for wound healing. ( How To Heal Wounds Faster? )
Clinically Proven and FDA-Approved: NexoBrid has completed thorough clinical trials and obtained FDA approval in the United States. Its safety and effectiveness have been confirmed in burn units across the globe.

NexoBrid dosage

The recommended dosage for NexoBrid is as follows:

Administration: It is necessary for NexoBrid to be given by a healthcare provider, and caution must be exercised to prevent exposure while preparing and handling it, such as wearing gloves and other protective gear.

Preparation: Before administration, it is necessary to mix the lyophilized powder with the gel vehicle. Each vial of powder, jar of gel, and the mixed NexoBrid are intended for single use on one patient for one application.

Available Forms:

2 grams of dried powder: contains 1.94 grams of anacaulase-bcdb, mixed in a gel vehicle at a concentration of 1% of the body surface area.
5 grams of dried powder: contains 4.85 grams of anacaulase-bcdb, mixed in a gel vehicle at a concentration of 2.5% of the body surface area.

Application: To form a protective barrier, use a skin protectant ointment around the treatment site. Administer NexoBrid with a 3 mm thick layer (similar to a tongue depressor) to an area of up to 15% BSA in one go. The combined treatment area should not exceed 20% BSA (equivalent to 40 grams of NexoBrid lyophilized powder) across two treatments.

Patient and Burn Wound Treatment Area Preparation:

Thoroughly cleanse the wound to eliminate charred tissue, blisters, and any topical products.

Cover the treatment area with a dressing soaked in an antibacterial solution for a minimum of two hours. Make sure the wound bed is free of any remaining topical agents.
Use a skin protectant ointment outside the treatment area as a protective barrier.
Protect open wounds with either skin protectant ointments or ointment gauze to avoid contact with NexoBrid.

NexoBrid Overdose

NexoBrid is a medication designed to eliminate eschar resulting from skin burns caused by heat or fire. It is effective for deep partial-thickness burns that penetrate the dermis layer, as well as full-thickness burns that extend through the entire dermis. NexoBrid contains a concentrated form of proteolytic enzymes with added bromelain.

While detailed information on NexoBrid overdose is not easily found, those who do experience an overdose could face heightened risks of serious side effects like pain and blood clotting issues. When this occurs, it is suggested that symptomatic and supportive treatments be used.

It is crucial to adhere to the recommended usage instructions for NexoBrid. The medication should not exceed 10% of the body surface area for children under 3 years and 15% for older individuals. NexoBrid should be left on the skin for 4 hours, and it is advised not to apply a second dose.

NexoBrid Substitutes

When looking for replacements for NexoBrid, a treatment for thermal burns, there are several other options worth exploring.

Allografts: These procedures utilize allogeneic skin grafts from a donor who is not genetically related. Allografts offer temporary natural coverage for burn injuries.
Xenografts: Xenografts, although easily accessible, may not be as successful as allografts, involving the use of skin grafts from a different species.
Human Amnion: The human amniotic membrane has been utilized for treating wounds, such as burn injuries, in wound care.

NexoBrid Interactions

If you are handling NexoBrid for treating thermal burns, here are the important details you should be aware of:

There are 46 moderate interactions identified between NexoBrid (anacaulase topical) and other drugs.

NexoBrid may interact with medications such as :

NexoBrid Interaction with medicine

NexoBrid is a gel applied to wounds for care. If you’re curious about how it interacts with other medications, here is some information you should be aware of:

There are 46 moderate drug interactions identified with NexoBrid (anacaulase topical) out of a total of 46 known drug interactions.

NexoBrid may interact with certain medications such as:

abciximab
alteplase
anagrelide
aspirin
clopidogrel
dabigatran
enoxaparin
heparin
warfarin
and more

NexoBrid Interaction with alcohol

NexoBrid is a topical gel designed for wound care, specifically to eliminate eschar – dead tissue – caused by burns from heat or fire. It is suitable for treating deep partial-thickness burns that reach the dermis, as well as full-thickness burns that extend even further into the dermis.

I don’t have detailed information on how NexoBrid interacts with alcohol in the sources I can find, but it is important to be careful when mixing any medication with alcohol. Some general factors to consider include:

Avoid Alcohol: It is recommended to refrain from drinking alcohol while using NexoBrid to avoid any potential interference with wound healing and to prevent aggravating skin sensitivity or inflammation.
Consult Your Healthcare Provider: It is important to always seek advice from your healthcare provider before mixing any medication with alcohol, as they can offer tailored recommendations according to your individual circumstances.
Individual Variability: It is important to keep in mind that different people may have varying reactions to alcohol and medications.
Safety First: Make your health a priority and adhere to your healthcare provider’s guidance. If you have any worries or encounter negative reactions, seek medical help right away.

Packages and Capabilities

NexoBrid is an innovative treatment for severe burns that has revolutionized the way burns are treated. Let’s explore its unique characteristics:

Indication: NexoBrid is utilized to remove eschar in situations involving intense partial and full-thickness burns. Eschar is the term for the deceased tissue that becomes brittle, thick, leathery, and dark as a result of skin burns caused by heat or fire.
Classification: It is considered an orphan biological drug.
Mechanism: NexoBrid is a highly concentrated solution of proteolytic enzymes, containing bromelain, that effectively removes eschar within four hours when applied topically, while protecting healthy surrounding tissues. Removing eschar is a crucial step in treating severe burns, and traditional methods like surgery or slow-acting topical agents come with their own risks. NexoBrid’s rapid and precise debridement reduces the risks associated with eschar, such as infection and scarring, and allows for better visualization of burn depth for treatment decisions.
Usage: NexoBrid is administered directly at the patient’s bedside. It effectively removes dead tissue without causing harm to healthy tissue after just a 4-hour application. This non-surgical debridement process at an early stage helps doctors assess the severity of burns and strategize the next steps in treatment. By reducing the need for surgery and protecting viable tissue, NexoBrid enhances overall results and can be easily applied by medical staff.

Storage

We should talk about the storage needs for NexoBrid.

Temperature:NexoBrid should be kept in a controlled environment with a temperature typically ranging from 20°C to 25°C or 68°F to 77°F.
Protection from Light:It is important to shield NexoBrid from direct sunlight or intense artificial light as exposure to light can reduce its effectiveness.
Original Packaging:Store NexoBrid in its original packaging until you are ready to use it to ensure stability and prevent contamination.
Avoid Freezing:It is not recommended to freeze NexoBrid as it can change its formulation and reduce its effectiveness.
Storage Duration:Follow the instructions provided by the manufacturer about the recommended shelf life of NexoBrid. Make sure to dispose of any vials that are expired or damaged.

Precautions

These are the safety measures to keep in mind when utilizing NEXOBRID for removing eschar in adult patients with deep partial thickness and/or full thickness thermal burns.

Hypersensitivity Reactions: Severe allergic reactions, including anaphylaxis, have been noted in patients who have used NEXOBRID after it was approved for marketing. If a hypersensitivity reaction occurs, discontinue NEXOBRID and start the necessary treatment.
Pain Management: It is important to effectively control pain during the lengthy process of changing dressings for burn wounds.
Contraindications: Previous allergic reactions to anacaulase-bcdb, bromelain, or pineapples, as well as any other ingredients, should be noted. There is also a risk of cross-sensitivity for individuals with known allergies to papayas or papain.
Handling Precautions: When working with NEXOBRID, make sure to take safety measures such as wearing gloves, surgical masks, and other protective gear. If the skin accidentally comes into contact with NEXOBRID, immediately wash it off with water to lower the risk of skin irritation.

Your Doubts : Best Answers

NexoBrid is administered topically, which involves directly applying it to the wound site. Here, we share Answers of mostly asked Questions or your doubts.

Can I take NexoBrid with food?

NexoBrid is a topical biological product specifically designed for treating patients with deep partial and full-thickness thermal burns by removing nonviable burn tissue (eschar). It works by enzymatically eliminating the eschar within four hours of application without causing harm to healthy tissue. It should be applied externally and not consumed orally or with food.

How to Keep Safe?

NexoBrid is a medication utilized to eliminate eschar resulting from skin burns caused by heat or fire. It is effective for both deep partial-thickness burns that reach the inner dermis layer, and full-thickness burns that penetrate even deeper. NexoBrid contains a potent mix of proteolytic enzymes with an enriched amount of bromelain as its active ingredient.

Below are some safety measures to remember when dealing with NexoBrid:

Exposure Precautions: When getting NexoBrid ready and dealing with it, make sure to protect yourself from exposure. This means wearing gloves, surgical masks, and any other necessary protective gear.
Skin Exposure: If NexoBrid comes into contact with your skin by accident, wash it off with water immediately to minimize the risk of developing skin sensitivities.

How to Know if it Effects You?

NexoBrid, which is a topical enzymatic agent, can influence the wound and the tissue around it. Here are ways to keep track of its effects.

Observation: Monitor the wound site carefully after using NexoBrid. Watch for any alterations in color, texture, or overall appearance, and take note of any decrease in necrotic tissue.
Pain and Discomfort: Mild discomfort during application is typical, but if you are feeling intense pain, make sure to notify your healthcare provider.
Redness and Swelling: It is normal to see some slight redness near the wound, but if there is significant redness or swelling, it could be a sign of a reaction.
Itching or Sensitivity: If you experience itching as a result of enzymatic action, it is important to seek medical advice if it becomes severe or long-lasting.
Allergic Reactions: Be aware of allergic reactions such as hives, rash, or itching not limited to the wound site and difficulty breathing or swelling in the face, lips, or throat. If you notice any of these symptoms, then use medical help.
Systemic Effects: While it is uncommon, systemic absorption might take place. Keep an eye out for any general symptoms like nausea, vomiting, or dizziness.

It is important to have regular check-ups with your healthcare provider to monitor the healing of your wound and to address any issues that may arise.

Can cause l NexoBrid problems?

NexoBrid is a type of enzymatic debridement product that is applied topically to help remove dead or damaged tissue in cases of severe burns. The product utilizes a high concentration of bromelain, an enzyme sourced from pineapple stems, for this purpose. Here are some points to keep in mind.

Application and Use: NexoBrid is directly administered to the burn wound to remove dead tissue and aid in wound healing. It is necessary to apply the treatment correctly and in the proper dosage.
Potential Side Effects and Risks: Similar to any other medication, NexoBrid may result in side effects, such as pain or discomfort during application, redness around the wound, and swelling or itching. Although serious allergic reactions are uncommon, they can still occur. It is important to adhere to the guidance provided by your healthcare provider.
Contraindications: NexoBrid is not recommended for use in certain circumstances.

If you have a history of allergies to bromelain or any other components, infected wounds without antibiotics, wounds close to important blood vessels or organs, or if you are pregnant or breastfeeding (with limited safety information), it’s important to consult a healthcare provider. Should you have any worries or encounter negative reactions, seek advice from your doctor. They will evaluate the advantages and drawbacks according to your individual situation.

How NexoBrid works?

NexoBrid is a medical treatment that effectively breaks down dead burn tissue, known as eschar, using a unique enzymatic process that spares healthy tissue.

Application: NexoBrid treatment involves directly applying the product to the burn wound of a patient with deep partial- or full-thickness thermal burns.
Enzymatic Action: NexoBrid includes an enzyme known as bromelain, derived from pineapple stems. This enzyme specifically targets and breaks down the nonviable eschar by digesting the proteins in the dead tissue while leaving the healthy surrounding tissue unharmed.
Speedy Eschar Removal: NexoBrid can dissolve the eschar within about four hours of application, which helps healthcare professionals get a clearer view of the wound for better treatment decisions.

Does it raise Blood Pressure?

NexoBrid is a topical biological product that does not cause an increase in blood pressure. It is utilized for removing nonviable burn tissue in patients with deep partial and full-thickness thermal burns. NexoBrid works by enzymatically dissolving the eschar in about four hours, leading to safer and more efficient treatment.

Can it Cause a Heart Attack?

NexoBrid is a topical biological product that is safe to use and does not lead to heart attacks. It is designed for patients with deep partial and full-thickness thermal burns to help remove nonviable burn tissue (eschar). By applying NexoBrid topically, the eschar is enzymatically dissolved within about four hours, leading to a more secure and efficient treatment.

Is the use of NexoBrid safe for pregnant women?

Limited research has been conducted on the safety of NexoBrid for pregnant women. Your doctor will evaluate the advantages and potential dangers to offer tailored recommendations according to your specific circumstances. It is important to prioritize your health and adhere to medical guidance from professionals.

What is the effect of NexoBrid on the Kidneys?

NexoBrid is a medicine that is used to remove dead tissue (eschar) resulting from skin burns from heat or fire.

Below are some important points:

Side Effects: The side effects most frequently linked to NexoBrid are:
Fever: Affects over 10% of the population.
Pain: Could impact as many as one out of every ten individuals. There is no specific reference to side effects related to the kidneys.
Drug Interactions: Bromelain in NexoBrid has shown to inhibit CYP2C8 in human hepatocytes in a time-dependent manner and also CYP2C9 in human microsomes. However, there have been no clinical studies done to evaluate the risk of systemic drug interactions.
Monitoring: NexoBrid is subject to heightened surveillance compared to other medications, with more intensive monitoring practices in place.

What is the effect on the Liver?

NexoBrid is a medication that is utilized to remove eschar, which is dead tissue that forms on the skin due to burns from heat or fire. It contains a potent mixture of proteolytic enzymes, specifically enriched with bromelain, that work to break down the eschar and facilitate its removal.

This is what we know about how it impacts the liver:

Inhibition of Liver Enzymes: NexoBrid enzymes block the activity of the liver enzymes CYP2C8 and CYP2C9 when taken in. It is unclear if this mechanism has any significance in a clinical setting.
Clinical Studies: There have been no specific clinical studies conducted to evaluate the possibility of systemic drug interactions with NexoBrid.
Common Side Effects: The most frequent side effects linked to NexoBrid are fever (experienced by over 1 in 10 individuals) and pain (reported by up to 1 in 10 individuals).

What is the effect on the Heart?

NexoBrid is a type of gel that is made up of enzymes and is applied to the skin, with a focus on removing dead skin tissue resulting from burns. This targeted action helps in promoting the growth of fresh, healthy skin and consequently speeds up the healing process of wounds.

While most side effects do not affect the heart, there is a chance that some people may experience cardiovascular related effects.

Is this medicine habit-forming or addictive?

NexoBrid is a non-addictive topical gel designed for managing burn wounds by targeting dead skin tissue. Although there may be some side effects, there is no risk of developing an addiction or habituation to this product. If you have any concerns about using NexoBrid, it is recommended to speak with your healthcare provider for personalized guidance.

Can this medicine be taken regularly?

NexoBrid is applied topically to the skin and is not ingested. It is designed for managing burn wounds by removing dead skin tissue. The frequency of using NexoBrid varies depending on the type of burn and should be determined by a healthcare provider. It is important to adhere to your doctor’s instructions regarding how and how often to use NexoBrid.

What happens when you use this expired medicine?

It is crucial to be aware of the potential risks associated with using expired NexoBrid.

Effectiveness: If NexoBrid is past its expiration date, its ability to break down dead skin tissue may be reduced as expired medications can lose their effectiveness.
Safety: The safety of expired medications can be different than when they are in date. While NexoBrid is typically safe if used properly, expired products may have different characteristics that could cause negative effects.
Side Effects: It is important to be cautious when using expired NexoBrid as it may lead to unforeseen side effects. If you notice any unusual symptoms after using expired medication, it is advisable to seek advice from a healthcare professional.
Disposal: Ensure you dispose of expired NexoBrid correctly by following local guidelines, refraining from flushing it down the toilet or tossing it in the trash.

Is NexoBrid (for Pain and fever) safer than others?

NexoBrid is not intended for treating pain and fever; it has a different role. Allow me to offer you accurate details about NexoBrid:

NexoBrid is intended for a specific purpose and is not used to manage pain or fever.
NexoBrid is approved for use in the European Union and is specifically designed to remove dead tissue from skin burns caused by heat or fire.
It contains a concentrated form of proteolytic enzymes, with a high level of bromelain.
It is suitable for treating both deep partial-thickness burns, which go into the inner layer of the skin known as the dermis, and full-thickness burns, which penetrate through the entire dermis.
NexoBrid has been deemed safe for use, but it is recommended that only healthcare professionals in specialized burn centers, who have received proper training, should administer it.

When not to use this?

NexoBrid is contraindicated in the following cases:

Allergic Reactions: It is important to avoid using NexoBrid if you have allergies to any of its ingredients.
Infected Wounds: NexoBrid is not recommended for treating infected wounds.
Face and Joints: Do not use NexoBrid on the face, joints, hands, feet, or genitals as these areas need special attention and may be better treated with other methods.
Pregnancy and Breastfeeding: There is insufficient data on the safety of using NexoBrid while pregnant or breastfeeding. It is recommended to seek advice from your healthcare provider before using it in these circumstances.
Children: The safety and effectiveness of NexoBrid in pediatric patients is not well established.
Severe Burns: In the case of severe burns covering more than 30% of the body, NexoBrid may not be the first-line treatment. It is recommended to seek guidance from a burn specialist for a comprehensive approach to management.

Can you drive after taking a normal dose of this medicine?

Only healthcare professionals are permitted to administer NexoBrid, a topical treatment used to remove eschar in severe second- and third-degree burns. Here are some important guidelines about its usage:

Administration: Healthcare professionals need to be careful when preparing and handling materials to prevent any potential exposure. They should use gloves, surgical masks, and other protective clothing.
Application: NexoBrid is administered directly onto the wound by a healthcare provider, and can be used twice if necessary, with a 24-hour gap between each application.
Driving: NexoBrid is applied externally and does not impact your overall bodily functions, so it should not hinder your driving ability. But it’s important to adhere to your healthcare provider’s guidance and take into account any pain management steps during the procedure.

Is this safe during breastfeeding?

Premature babies, newborns, and medically unstable infants or those with kidney issues are at the highest risk from medication exposure through breast milk. Nevertheless, the levels of medication transferred to your baby in the first two days after birth are very minimal, as the volume of breast milk produced during this time is limited.

Can this Tablet be used during Pregnancy?

Some medications should be avoided during pregnancy due to the risk of causing serious birth defects and complications, such as certain pain relievers and cold remedies. On the other hand, there are medications that are considered safe for use during pregnancy. Over-the-counter and prescription medications are commonly used by pregnant individuals in the United States, with a majority relying on them for treatment.

How to use the NexoBrid?

NexoBrid gel is used in a 2 g/20 g ratio for burn wounds of 100 cm and in a 5 g/50 g ratio for burn wounds of 250 cm . The gel should be applied within 15 minutes of mixing and should be left on the skin for four hours. It is not advisable to apply a second dose of NexoBrid.

How long does this medicine take to show its effect?

NexoBrid is a medication designed to eliminate dead tissue, known as eschar, resulting from burns caused by heat or fire. It can effectively treat deep partial-thickness burns (also termed as ‘second degree’ burns) as well as full-thickness burns (also termed as ‘third degree’ burns). The key ingredient in NexoBrid is a potent blend of proteolytic enzymes that are enriched with bromelain.

Now, let’s discuss the duration it takes for NexoBrid to demonstrate its efficacy.

Eschar Removal: NexoBrid is designed for the precise purpose of removing dead tissue in patients with deep partial- and full-thickness thermal burns. By doing so, it helps improve wound management and promote healing in these individuals.
Speed of Action: The time it takes for NexoBrid to demonstrate its effectiveness may differ depending on individual circumstances, the burn’s severity, and the specific situation. Nonetheless, NexoBrid is created to act rapidly by enzymatically breaking down the eschar.
Clinical Studies: Clinical research has shown that NexoBrid is successful in removing eschar and aiding in the healing of wounds. However, the exact start of its effects may vary among different individuals.
Common Side Effects: It is important to be aware that NexoBrid can cause side effects, with the most common ones being fever (affecting more than 1 in 10 people) and pain (affecting up to 1 in 10 people). These side effects are typically mild and are associated with the treatment itself.
Consultation with Healthcare Provider: It is essential to adhere to the recommended treatment plan and seek guidance from a healthcare professional if you or a loved one is using NexoBrid. They can offer personalized details on when to expect the removal of dead tissue and track the healing process.

How many times a day does this need to be taken?

Healthcare providers administer NexoBrid, a topical debriding agent, for treating burn wounds. Below are the important details about how it is dosed and administered:

Application Frequency: It can be used for two treatments lasting up to four hours each. The initial treatment can be for a maximum of 15% of the body surface area, and a follow-up treatment can be done 24 hours later. The total combined treated area should not exceed 20% of the body surface area.

Preparation and Application:

Before using NexoBrid, medical professionals need to ensure to:

Thoroughly cleanse the wound area.
Dress the wound with an antibacterial-soaked dressing for a minimum of 2 hours.
Remove any remnants of topical agents from the wound bed.
Apply a skin protectant ointment around the treatment area to create a barrier.
Protect any open wounds with a skin protectant ointment to avoid contact with NexoBrid.
NexoBrid should be applied as a 3 mm thick layer (about the thickness of a tongue depressor) on up to 15% of the body surface area in one go.
If the wound surpasses 15% BSA, it can be treated in two separate sessions.
The second application, whether on the same or a new burn area, should be carried out 24 hours after the first application.
The combined treatment area for both sessions should not go beyond 20% BSA.

Precautions: Healthcare professionals need to be careful when dealing with NexoBrid to prevent exposure. It is only meant for topical application. Apply a skin protectant ointment around the treatment site as a protective barrier. Make sure to manage pain effectively before undertaking any procedures involving NexoBrid.

Should this taken on an empty stomach or before meals or after meals?

This is a topical gel that is utilized for the removal of dead tissue (eschar) in adult patients who have severe burns of deep partial thickness and/or full thickness burns. Below are the guidelines for its application.

Dosage and Administration:

Topical use only: Administer NexoBrid directly onto the wound site, with the option of applying it in two sessions of 4 hours each. The initial application can cover a maximum of 15% of the body surface area, followed by a second application 24 hours later. The combined treated area for both applications should not exceed 20% of the body surface area.
Preparation and Application: Clean the wound area thoroughly to remove any charred tissue, blisters, and topical products before treatment. Put on a dressing with an antibacterial solution on the treatment area for a minimum of 2 hours. Make sure the wound is free of any leftover topical products. Use NexoBrid on a wet, clean wound bed without burnt skin or blisters. Cover the area with an occlusive dressing for 4 hours.
Limitations of Use: NexoBrid should not be used on wounds that are contaminated with radioactive or other dangerous substances. It is not approved for treating chemical or electrical burns, burns on certain body parts (face, perineum, genitalia), or burns that go all the way around a body part. It is also not advised for patients with serious heart or lung issues or inhalation injuries.

Is NexoBrid medicine habit-forming or addictive?

It is not addictive and is intended to help wound healing by getting rid of non-viable tissue enzymatically. If you have any uncertainties about using NexoBrid, it’s best to seek guidance from your healthcare provider.

Can I take this Tablet if I have hepatitis?

This is applied as a topical gel for removing eschar in adult patients with deep partial thickness and/or full thickness thermal burns, rather than being taken in tablet form. This means that there are no worries about potential interactions with conditions like hepatitis or other internal issues.

If you have any particular medical issues or conditions, it is advisable to seek advice from your healthcare provider. They can offer tailored guidance based on your unique health circumstances. It is important to adhere to your doctor’s recommendations regarding medication or therapy.

Is NexoBrid FDA approved?

This topical treatment, made from bromelain-based enzymes, is approved in 43 countries including the EU. It is classified as an orphan biologic drug in the US and other markets globally.

How much does it cost?

The price of NexoBrid, a topical gel for removing eschars in adults with deep partial thickness and/or full thickness thermal burns, can fluctuate depending on the pharmacy and amount purchased. Below are some estimated costs.

NexoBrid Topical Gel (8.8%): Cash-paying customers can expect to pay approximately $3,326 for a 55-gram supply of medication when using the Drugs.com discount card, which is widely accepted at most pharmacies in the United States.
GoodRx Price: The least expensive price for NexoBrid on GoodRx is $6.42.

Who makes NexoBrid?

It is made by MediWound Ltd,an Israeli biopharmaceutical company that specializes in creating new treatments for severe burns and long-term wound care. They are dedicated to creating and selling products that fill gaps in medical care for these conditions. If you have more inquiries or need more details, please don’t hesitate to reach outout.

When it is approved?

Regulatory authorities have given approval for the use of NexoBrid in the treatment of severe burns. The specific approval dates may differ depending on the country, but the medication has been authorized for use in different regions. For precise approval dates in a specific country, it is advisable to verify with local health authorities or refer to official documents from MediWound Ltd., the manufacturer of NexoBrid.

What is the mechanism of action?

It helps to remove dead tissue from severe burns using a unique and interesting process. Let me explain it to you:

Enzymatic Debridement: NexoBrid contains bromelain, an enzyme sourced from pineapples, that possesses exceptional properties. When used on a burn wound, bromelain selectively attacks and disintegrates the proteins in the eschar, specifically breaking down the peptide bonds in the dead tissue while leaving healthy tissue unharmed.

When bromelain is applied to a burn wound, it specifically targets and breaks down the proteins in the hard, dead tissue covering the burn area.

Conclusion

It assists in the removal of dead tissue from burns, enabling safer and more efficient treatment. Doctors use NexoBrid to make a more timely and knowledgeable decision regarding additional treatment options. It has been classified as an orphan biologic drug in the US, EU, and other global markets. NexoBrid has been approved in 42 countries and is currently in the process of being registered with the U.S. Food and Drug Administration (FDA).