Combiflam Tablet : What is Combiflam Used for, Tab Combiflam, Combiflam Uses, Side Effects

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: Combiflame is a combination of ibuprofen and paracetamol. It is mainly used for the relief of pain and fever. It is one of the most used medicines in India.


It also has antipyretic properties. Its major side effect is liver damage, which occurs on repeated use at high doses.

Combiflam should be avoided for those who have a gastric ulcer or any liver disease.

  • Composition – paracetamol 325 mg + ibuprofen 400 mg
  • Created by – Sanofi India Limited
  • Prescription – Required (belongs to Schedule ‘H’) but also available as OTC
  • Features – Tablets
  • Price – 28.63 (20 tablets)
  • Expiry – 24 months from date of manufacture
  • Drug type – Analgesic, and antipyretic


Combiflam serves as a dual purpose as it works for pain as well as fever. It is prescribed for the following:

1. Fever:

It is used for fever because it contains paracetamol which is anti-pyretic in nature.

2. Headache:

Used as a pain reliever because it contains Ibugesic (NSAIDs).

3. Muscle pain:

Used to treat muscle pain in the case of osteoarthritis and gout.

4. Menstrual Cramps:

Used to treat stomach cramps during the menstrual cycle in women.

5. Toothache:

It uses to treat mild to moderate pain in the teeth.

Combiflam Tablet Composition

  • Combiflam Tablet: Ibuprofen (400 mg), Paracetamol (325 mg).
  • Tablet (Combiflam Tablet): Ibuprofen (100 mg), Paracetamol (162.5 mg).
  • Tablet (Combiflam Plus Tablet): Caffeine (50 mg), Paracetamol (650 mg).
  • CombiflamIcyHot 15 GM Gel: Diclofenac Diethylamine (1.16% w / w), Methyl Salicylate (10% w / w), Menthol (5% w / w), Virgin Linseed Oil (3% w / w).
  • CombiflamIcyHot 35 GM Gel: Diclofenac Diethylamine (1.16% w / w), Methyl Salicylate (10% w / w), Menthol (5% w / w), Virgin Linseed Oil (3% w / w).

How does Combiflam Work?

By inhibiting the Cyclo-oxygenase (COX) enzyme combiflam works. which further inhibits the production of prostaglandins which are the reason behind the onset of pain.

Prostaglandins cause pain, swelling, and redness at the site of injury.

Therefore, when the production of COX enzymes interrupt. The production of prostaglandin also disrupt which in turn reduces pain, and increases blood flow to the skin.

Ibuprofen and paracetamol inhibit COX enzymes and reduce pain.

How to Take Combiflame?

Combiflam is commonly available in tablet and suspension forms.

Usually, the tablets use orally (via mouth) with a glass of water as instructed by the physician.

It should be taken with food or after a meal, and not with an empty stomach because the acidic content of the empty stomach can affect the medicinal activity of the tablet and may even affect the stomach.

The tablet should never be crushed or chewed.

Before consuming the suspension form of combiflam, the homogenous mixture of the drug should be stirred properly.

The patient advise to go through the leaflet inside the package to have a better understanding of the medicine.

The Usual Dose for Combiflam

According to the patient’s age, weight, mental state, history of allergy, the dosage of the drug should be fixed for each person.

The usual dose of Combiflam determine according to the severity of the pain and there should be a difference of at least 4-6 hours between the two doses.

When to Avoid Combiflame?

Do not consume Combiflam Tablet in the following scenarios:


Induces an allergic reaction to combiflam (paracetamol, ibuprofen) or other NSAIDs (aspirin, diclofenac).


An asthma attack, irritation, and inflammatory condition on the nose and face in cases of Combiflam or other NSAIDs.

Gastric problems

In known cases of the intestine or stomach ulcers, because comfiflam can create stomach bleeding.

Liver diseases

In cases of past or present condition of liver problems.

Kidney diseases

In the case of kidney diseases in past or present condition.

Heart disease: In cases of the current state or history of heart diseases such as heart failure or stroke.

Blood disorders

In cases of blood disorders like porphyria and also in cases where the patient is more likely to have bleeding.

Precautions While Taking Combiflame

Empty stomach:

Do not take Combiflam empty stomach as it may reduce the efficacy of the drug and may also cause stomach upset.

Allergic reaction

Any allergic reaction should be reported to the doctor immediately.

Avoid overdose

The overdose of medicine should be avoided.

Time interval

To avoid increased levels of the drug in the blood, an interval of 4-6 hours should be maintained between the two doses as it may cause toxicity.

Warning While Taking Combiflame

Consuming more than the prescribed dose daily can cause liver damage and severe allergic reactions like swelling of face, lips, throat.

With a history or currently suffering from bronchial asthma, bronchospasm may occur in patients.

Patients in whom aspirin or other NSAIDs induce asthma, rhinitis, or urticaria symptoms should not take Combiflam or any other drugs containing ibuprofen.

Combiflame Side-Effects

The following are the side effects associated with Combiflam tablets used for various treatments:

  • Hartburn – General
  • Vertigo – General
  • Rash itchy skin – rare
  • Liver poisoning – rare but major side effects due to repeated overdose of the drug
  • Dizziness – Less common
  • Nausea – normal
  • Epigastric discomfort – less common
  • Indigestion – Less Common
  • Insomnia – Less Common
  • Diarrhea – General
  • Stomach ache – less common
  • Gastritis (if taken often on an empty stomach)
  • Vomiting – less common
  • Mouth Ulcers – Less Common
  • Constipation – General
  • Decreased urine output – rare
  • Yellowing of eyes/skin – Decreased

Allergic Reactions (Combiflam Tablet)

The possible allergic reactions reported for Combiflam tablets are:

  • Extreme pain – Less common
  • Wheezing – General
  • Difficulty breathing – Less common
  • Vomiting – Normal
  • Rare itching and skin rashes and itching are rare but can be caused by an allergy to combiflam
  • Sores tender (painful) on mouth and lips – Rare

Effects of Combiflam Tablets on Organes

Combiflam dose should be reduced in patients with liver disease as high doses of paracetamol may increase the likelihood of further liver damage.

The doctor should be consulted before taking Combiflam Tablet. If someone is suffering from kidney disease, appropriate dose adjustment and monitoring of kidney function is mandatory in such cases.

Interaction with Combiflam Tablet

Some medicines should be cautious when taking Combiflame. These may include some tests ranging from certain foods to other medications, which should not be correct after intake of Combiflame.

Its details are below:

Food Interaction with Combiflame

Apart from alcohol, no particular food item can be avoided as it can cause liver damage.

Drug interactions with Combiflame

Not all possible drug interactions can be listed here. It is always advised that the patient should inform the doctor about all the drugs/products you use.

You should also give information about the herbal products that you are consuming. Without your doctor’s approval, You should not modify the revision of the medicine.

The drug interactions have their own consequences and effects, which can be further identified as mild or severe:

  • Cholestyramine and metoclopramide (cholesterol-lowering elements) (mild)
  • Some nonalcoholic analgesics such as diflunisal (mild)
  • Anticonvulsant drugs -Carbamazepine (mild)
  • Antibiotics like quinoline, isoniazid (mild), amobarbital, butalbital, pentobarbital, phenobarbital.
  • Hydentase, long-term exposure to rifampin increases the likelihood of toxicity. (serious)
  • Steroids (Mild): Increases the risk of gastrointestinal bleeding.
  • Other non-steroidal anti-inflammatory agents such as aspirin, ibuprofen (severe): An increase in the concentration of NSAIDs in the blood may cause gastric irritation and in some cases bleeding.
  • Diuretics (drugs used to increase the rate of urinary excretion) (mild): Increases the likelihood of kidney damage. Medications used to lower blood sugar levels in diabetics
  • Methotrexate (used to treat cancer, arthritis) (severe): As it may cause bleeding and breathing problems when taken with Combiflame
  • Ciclosporin and tacrolimus (drugs used to suppress the immune system).
  • Zidovudine (a drug used to treat HIV) (mild).
  • Medications used to treat high blood pressure (antihypertensive) (mild).
  • Digoxin (used to treat the failure of heart and heartbeat irregularity).

Effect of Combiflame on Lab Test

In high doses of repetition, there is no effect on any laboratory tests other than the potential damage to the liver.

Storage Requirements for Combiflam Tablets

In a moisture-free place, cool at temperatures below 25o, the drug should be stored.
The medicine should be kept in a place where it is out of the reach of children.

Q & A (Combiflam Tablets)

Ques: What is combiflame?

Ans: Combiflam is not basically a single drug; It is a combination of two drugs: ibuprofen and paracetamol.

It serves a dual purpose as it has analgesic (reduces pain) and antipyretic (reduces fever) properties.

It is mostly used to treat mild to moderate pain. It can also be used in cases of fever as it also has antipyretic properties.

Ques: What are the uses of Combiflam?

Ans: Combiflam works for both pain as well as fever. It is usually taken in cases of headache, muscle aches, menstrual cramps, and toothache.

Ques: What are the side effects of Combiflam?

Ans: The most commonly Combiflam have side effects are heartburn, dizziness, nausea, diarrhea, and constipation.

Ques: Can I have Combiflam with alcohol?

Ans: No, it increased the risk of liver damage. The consulting physician should be informed immediately if any signs appear that indicate abdominal bleeding (cough or dry and coffee colored blood in the stool).

Q & A (Combiflam Tablets)

Ques: Which special foods should be avoided?

Ans: There is no need to avoid any special foods when taking Combiflam.

Ques: Can I take Combiflam while pregnant?

Ans: The doctor should always be informed if you are pregnant or planning to become pregnant as Combiflame recommend for pregnant women.

Ques: Can Combiflame be taken while breastfeeding the infant?

Ans: The doctor should always be informed if you are breastfeeding your baby as a precaution because COMPFLAM is not recommended for a breastfeeding mother.

Ques: Can I drive after taking Combiflame?

Ans: Anyone can drive after taking Combiflam, but if there is any dizziness or drowsiness, then driving should be avoided.

Q & A (Combiflam Tablets)

Ques: How effective is combiflame?

Ans: Combiflame is effective as a pain reliever due to its pain-relieving properties.

However, as an antipyretic, there are other drugs that have better performance when used for treating fever.

Ques: How long does combiflame take to show results?

Ans: Combiflam drug relieves fever and pain within 30-45 minutes.

Ques: Should Combiflam be taken on an empty stomach?

Ans: It should not be taken on an empty stomach as the components may cause stomach irritation and in rare cases of patients already suffering from gastric ulcer or any other gastric problem, bleeding may occur.

Q & A (Combiflam Tablets)

Ques: Does Combiflame Drunk You?

Ans: In some cases, it can cause drowsiness, but it varies with every person

Ques: What happens if I overdose on Combiflame?

Ans: In the case of combiflam overdose, a doctor should be consulted immediately.

Ques: What happens if I forget to take a dose of Combiflam?

Ans: The drug may not show the proper effect if you miss a dose, because, for the effective functioning of the drug, a certain amount of medicine must be present in your body at all times.

Always take the forgotten dose as soon as you remember it.

However, if you have already taken a second dose, do not take double doses as it may cause drug overdose.

Q & A (Combiflam Tablets)

Ques: What happens if I take expired medication?

Ans: adverse event is unlikely to occur with a single dose of expired medicine.

However, if someone feels unwell or ill after taking an expired medicine, medical advice should be taken. It is advisable to avoid using expired medicine.

Ques: What is the start time of combiflame?

Ans:  pills show results in about 30–45 minutes.

Ques: How long does Combiflam last?

The effect of Combiflam lasts for 5 to 6 hours.

Q & A (Combiflam Tablets)

Ques: What should be the time difference between the intake of Combiflam Tablet?

Ans: An ideal time interval of at least 4-6 hours should be between the two doses to avoid combiflame poisoning.

Ques: Should I complete the entire cycle of medicine even when I am recovering?

Ans: Combiflam relieves symptoms such as fever and pain if the symptoms disappear completely, then one can gradually close the drug cycle.

Ques: Does Combiflam affect my menstruation?

Ans: The effects of Combiflam on the menstrual cycle is not known. Consult the doctor in case of current menstrual problems before consuming the drug.

Q & A (Combiflam Tablets)

Ques: is Combiflame safe for children?

Ans: Combiflam should not be consumed in children under 1 year of age without consulting a pediatrician.

Children are unable to take tablets. Thus, Combiflam Syrup may be advised in such cases.

Ques: Are there any symptoms that I should assume before consuming Combiflam?

Ans: Gastric irritation and liver related problems should be taken into consideration before consuming Combiflam.

Q & A (Combiflam Tablets)

Ques: Is Combiflam legal in India?

Ans: Yes, it is legal and manufactured by Sanofi India Limited.


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